AustralieFrV1, Main, Exploration, bibRecord, 003686

New insights on contraction efficiency in patients with Duchenne muscular dystrophy

Identifieur interne : 003686 ( Main/Exploration ); précédent : 003685; suivant : 003687

New insights on contraction efficiency in patients with Duchenne muscular dystrophy

Auteurs : Lilian Lacourpaille [France] ; François Hug [France, Australie] ; Arnaud Guével [France] ; Yann Péréon [France] ; Armelle Magot [France] ; Jean-Yves Hogrel [France] ; Antoine Nordez [France]

Source :

Journal of Applied Physiology [ 8750-7587 ] ; 2014.

RBID : PMC:4157166

Descripteurs français

KwdFr :
- Adolescent, Bras (physiopathologie), Contraction musculaire, Enfant, Enfant d'âge préscolaire, Femelle, Force musculaire, Humains, Imagerie d'élasticité tissulaire, Jeune adulte, Muscles squelettiques (imagerie diagnostique), Muscles squelettiques (physiopathologie), Myopathie de Duchenne (imagerie diagnostique), Myopathie de Duchenne (physiopathologie), Mâle, Nourrisson, Stimulation électrique, Transmission synaptique.
MESH :
- imagerie diagnostique : Muscles squelettiques, Myopathie de Duchenne.
- physiopathologie : Bras, Muscles squelettiques, Myopathie de Duchenne.
- Adolescent, Contraction musculaire, Enfant, Enfant d'âge préscolaire, Femelle, Force musculaire, Humains, Imagerie d'élasticité tissulaire, Jeune adulte, Mâle, Nourrisson, Stimulation électrique, Transmission synaptique.

English descriptors

KwdEn :
- Adolescent, Arm (physiopathology), Child, Child, Preschool, Elasticity Imaging Techniques, Electric Stimulation, Female, Humans, Infant, Male, Muscle Contraction, Muscle Strength, Muscle, Skeletal (diagnostic imaging), Muscle, Skeletal (physiopathology), Muscular Dystrophy, Duchenne (diagnostic imaging), Muscular Dystrophy, Duchenne (physiopathology), Synaptic Transmission, Young Adult.
MESH :
- diagnostic imaging : Muscle, Skeletal, Muscular Dystrophy, Duchenne.
- physiopathology : Arm, Muscle, Skeletal, Muscular Dystrophy, Duchenne.
- Adolescent, Child, Child, Preschool, Elasticity Imaging Techniques, Electric Stimulation, Female, Humans, Infant, Male, Muscle Contraction, Muscle Strength, Synaptic Transmission, Young Adult.

Abstract

The decrease in muscle strength in patients with Duchenne muscular dystrophy (DMD) is mainly explained by a decrease in the number of active contractile elements. Nevertheless, it is possible that other electrochemical and force transmission processes may contribute. The present study aimed to quantify the effect of DMD on the relative contribution of electrochemical and force transmission components of the electromechanical delay (i.e., time lag between the onset of muscle activation and force production) in humans using very high frame rate ultrasound. Fourteen patients with DMD and thirteen control subjects underwent two electrically evoked contractions of the biceps brachii with the ultrasound probe over the muscle belly. The electromechanical delay was significantly longer in DMD patients compared with controls (18.5 ± 3.9 vs. 12.5 ± 1.4 ms, P < 0.0001). More precisely, DMD patients exhibited a longer delay between the onset of muscle fascicles motion and force production (13.6 ± 3.1 vs. 7.9 ± 2.0 ms, P < 0.0001). This delay was correlated to the chronological age of the DMD patients (r = 0.66; P = 0.01), but not of the controls (r = −0.45; P = 0.10). No significant difference was found for the delay between the onset of muscle stimulation and the onset of muscle fascicle motion. These results highlight the role of the alteration of muscle force transmission (delay between the onset of fascicle motion and force production) in the impairments of the contraction efficiency in patients with DMD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157166

DOI: 10.1152/japplphysiol.00544.2014
PubMed: 25103971
PubMed Central: 4157166

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Arm (physiopathology)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Elasticity Imaging Techniques</term>
<term>Electric Stimulation</term>
<term>Female</term>
<term>Humans</term>
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<term>Enfant d'âge préscolaire</term>
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<term>Myopathie de Duchenne (physiopathologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Stimulation électrique</term>
<term>Transmission synaptique</term>
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<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Muscle, Skeletal</term>
<term>Muscular Dystrophy, Duchenne</term>
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<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Muscles squelettiques</term>
<term>Myopathie de Duchenne</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Bras</term>
<term>Muscles squelettiques</term>
<term>Myopathie de Duchenne</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arm</term>
<term>Muscle, Skeletal</term>
<term>Muscular Dystrophy, Duchenne</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Elasticity Imaging Techniques</term>
<term>Electric Stimulation</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Muscle Contraction</term>
<term>Muscle Strength</term>
<term>Synaptic Transmission</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Contraction musculaire</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Force musculaire</term>
<term>Humains</term>
<term>Imagerie d'élasticité tissulaire</term>
<term>Jeune adulte</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><p>The decrease in muscle strength in patients with Duchenne muscular dystrophy (DMD) is mainly explained by a decrease in the number of active contractile elements. Nevertheless, it is possible that other electrochemical and force transmission processes may contribute. The present study aimed to quantify the effect of DMD on the relative contribution of electrochemical and force transmission components of the electromechanical delay (i.e., time lag between the onset of muscle activation and force production) in humans using very high frame rate ultrasound. Fourteen patients with DMD and thirteen control subjects underwent two electrically evoked contractions of the biceps brachii with the ultrasound probe over the muscle belly. The electromechanical delay was significantly longer in DMD patients compared with controls (18.5 ± 3.9 vs. 12.5 ± 1.4 ms, <italic>P</italic>
 < 0.0001). More precisely, DMD patients exhibited a longer delay between the onset of muscle fascicles motion and force production (13.6 ± 3.1 vs. 7.9 ± 2.0 ms, <italic>P</italic>
 < 0.0001). This delay was correlated to the chronological age of the DMD patients (<italic>r</italic>
 = 0.66; <italic>P</italic>
 = 0.01), but not of the controls (<italic>r</italic>
 = −0.45; <italic>P</italic>
 = 0.10). No significant difference was found for the delay between the onset of muscle stimulation and the onset of muscle fascicle motion. These results highlight the role of the alteration of muscle force transmission (delay between the onset of fascicle motion and force production) in the impairments of the contraction efficiency in patients with DMD.</p>
</div>
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</settlement>
</list>
<tree><country name="France"><region name="Pays de la Loire"><name sortKey="Lacourpaille, Lilian" sort="Lacourpaille, Lilian" uniqKey="Lacourpaille L" first="Lilian" last="Lacourpaille">Lilian Lacourpaille</name>
</region>
<name sortKey="Guevel, Arnaud" sort="Guevel, Arnaud" uniqKey="Guevel A" first="Arnaud" last="Guével">Arnaud Guével</name>
<name sortKey="Hogrel, Jean Yves" sort="Hogrel, Jean Yves" uniqKey="Hogrel J" first="Jean-Yves" last="Hogrel">Jean-Yves Hogrel</name>
<name sortKey="Hug, Francois" sort="Hug, Francois" uniqKey="Hug F" first="François" last="Hug">François Hug</name>
<name sortKey="Magot, Armelle" sort="Magot, Armelle" uniqKey="Magot A" first="Armelle" last="Magot">Armelle Magot</name>
<name sortKey="Magot, Armelle" sort="Magot, Armelle" uniqKey="Magot A" first="Armelle" last="Magot">Armelle Magot</name>
<name sortKey="Nordez, Antoine" sort="Nordez, Antoine" uniqKey="Nordez A" first="Antoine" last="Nordez">Antoine Nordez</name>
<name sortKey="Pereon, Yann" sort="Pereon, Yann" uniqKey="Pereon Y" first="Yann" last="Péréon">Yann Péréon</name>
<name sortKey="Pereon, Yann" sort="Pereon, Yann" uniqKey="Pereon Y" first="Yann" last="Péréon">Yann Péréon</name>
</country>
<country name="Australie"><noRegion><name sortKey="Hug, Francois" sort="Hug, Francois" uniqKey="Hug F" first="François" last="Hug">François Hug</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003686 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003686 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4157166
   |texte=   New insights on contraction efficiency in patients with Duchenne muscular dystrophy
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25103971" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

New insights on contraction efficiency in patients with Duchenne muscular dystrophy

New insights on contraction efficiency in patients with Duchenne muscular dystrophy

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Descripteurs français

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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